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Titre : Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance
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Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance

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Clinical Infectious Diseases, ciy965, https://doi.org/10.1093/cid/ciy965

Published: 02 February 2019

Testosterone in Men With Chronic Hepatitis C Infection and After Hepatitis C Viral Clearance

We evaluated testosterone levels and the prevalence of low testosterone in a cohort of 327 men with chronic HCV infection (human immunodeficiency virus [HIV] coinfection = 150) and in a subset of 85 men with testosterone levels obtained pre-HCV treatment and after sustained virologic response (SVR). Median follow-up was 36 months.

Full text available online:

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy965/5305922

Commentary: Healio

In the Journals Plus 

Low testosterone persists after HCV clearance

February 11, 2019 

Low levels of free testosterone are common among men with chronic hepatitis C infection following SVR and persist after HCV clearance, according to findings from a prospective, longitudinal cohort study.

“Previous research has shown that low total testosterone (TT), low free testosterone (FT), and elevated sex hormone-binding globulin (SHBG) are extrahepatic manifestations of chronic HCV when compared with healthy controls,” Chloe S. Chaudhury, MD, post-baccalaureate research fellow at the National Institute of Allergy and Infectious Diseases, and colleagues wrote. “There is now a need for studies to examine the effect of HCV and HCV viral clearance on long-term testosterone levels and hypogonadal status.” 

Read more:

https://www.healio.com/infectious-disease/hepatitis-c/news/in-the-journals/%7B7d2a2378-dfaa-4ed9-baaf-81eda7ea5355%7D/low-testosterone-persists-after-hcv-clearance

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