EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy - Hallo friend NEWS AN INSPIRATION, In the article you read this time with the title EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy, we have prepared well for this article you read and download the information therein. hopefully fill posts Article ECONOMY, Article HEALTH, Article POLITICS, Article SPORTS, Article TRAVELING, Article UPDATE, we write can understand. Well, happy reading.

Titre : EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy
link : EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy

EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy

Clin Transl Sci. 2018 Jul 24. doi: 10.1111/cts.12564. [Epub ahead of print]

No Pharmacokinetic Interactions Between Elbasvir or Grazoprevir and Methadone in Participants Receiving Maintenance Opioid Agonist Therapy

Feng HP1, Guo Z1, Caro L1, Marshall WL1,2, Liu F1, Panebianco D1, Vaddady P1, Reitmann C1, Jumes P1, Wolford D1, Fraser I1,3, Valesky R1, Martinho M1, Butterton JR1, Iwamoto M1, Webster L4,5, Yeh WW1.

Link

Download Full Text Article
View Online

Abstract
We conducted two phase I trials to evaluate the pharmacokinetic interactions between elbasvir (EBR), grazoprevir (GZR), and methadone (MK-8742-P010 and MK-5172-P030) in non-hepatitis C virus (HCV)-infected participants on methadone maintenance therapy. Coadministration of EBR or GZR with methadone had no clinically meaningful effect on EBR, GZR, or methadone pharmacokinetics. The geometric mean ratios (GMRs) for R- and S-methadone AUC0-24 were 1.03 (90% confidence interval (CI), 0.92-1.15) and 1.09 (90% CI, 0.94-1.26) in the presence/absence of EBR; and 1.09 (90% CI, 1.02-1.17) and 1.23 (90% CI, 1.12-1.35) in the presence/absence of GZR. The GMRs for EBR and GZR AUC0-24 in participants receiving methadone relative to a healthy historical cohort not receiving methadone were 1.20 (90% CI, 0.94-1.53) and 1.03 (90% CI, 0.76-1.41), respectively. These results indicate that no dose adjustment is required for individuals with HCV infection receiving stable methadone therapy and the EBR/GZR fixed-dose regimen. PMID: 30040872 DOI: 10.1111/cts.12564

Continue to article: https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12564

Thus articles EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy

that is all articles EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy This time, hopefully can provide benefits to you all. Okay, see you in another article post.

You are now reading the article EBR/GZR safe/effective for people with HCV receiving opioid agonist therapy the link address https://newsaninpiration.blogspot.com/2018/07/ebrgzr-safeeffective-for-people-with.html

Tweet

Subscribe to receive free email updates: