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TGIF! HCV-related diseases and How hepatitis C converts innocent cells into virus factories

TGIF! Welcome to a review of this week's news, research and updates around the web.

In The News
Oct 13
How hepatitis C wages guerrilla warfare
Kari Williamson
How hepatitis C converts innocent cells into virus factories
The Hepatitis C (HCV) virus is a sly enemy to have in one’s body. Not only does it manage to make itself invisible to the immune system by breaking down communication between the immune cells, it also builds secret virus “factories” that quickly go into mass production.

It takes one to three months from infection to disease, and in the worst case scenario can lead to liver failure and death over time.

After an intense hunt, NTNU researchers can now describe an important part of the disease’s guerrilla tactics: how hepatitis C converts innocent cells into outright virus factories

New Online - HCV-related diseases
In case you haven't heard, HCV Advocate has launched a series of patient-friendly articles about the Extrahepatic Manifestations of Hepatitis C, written by Alan Franciscus.

Provided below is the latest articles in the series, make sure not to miss new articles published later this month, sign up here to receive updates, follow HCV Advocate on Twitter or connect on Facebook. Find out what's new, here!

HCV Advocate Index - Extrahepatic Manifestations of Hepatitis C
Oct 11
Hepatitis C and Porphyria Cutanea Tarda (PCT)
Oct 10
The Hepatitis C Connection – Fibromyalgia
Oct 5
Diabetes
Oct 3
Mixed Cryoglobulinemias

Just So You Know
Research has demonstrated that two-thirds of individuals with HCV infection experienced extrahepatic manifestations over the course of their disease. The good news is treating HCV early, and curing the virus, is shown to "reduce symptoms and mortality from severe extrahepatic manifestations."

On This Blog
A collection of current research articles on ailments related to HCV
Categorized article directory on the extrahepatic manifestations of hepatitis C.

Coverage from the International Conference on Viral Hepatitis (ICVH) 2017
October 09 - 10, 2017
Chicago, Illinois
Medscape Gastroenterology
Hep C Treatment Increasingly Feasible in Primary Care

Oct 12

CHICAGO — With highly effective treatments for hepatitis C becoming less expensive, it is no longer necessary for subspecialists to treat most patients with this ...

Begin here.....

Oct 11
Medscape Gastroenterology - Hepatitis C Cure 'Difficult to Implement'

CHICAGO — Although new treatments can effectively cure most cases of hepatitis C, outdated guidelines, too many treatment choices, and lack of insurance coverage can make standards of care difficult to implement, experts acknowledge...

Begin here.....

Hepatitis Barriers to Care Focus of ICVH 2017

"We have drugs that can cure hepatitis C in 8 to 12 weeks, but we don't have means to test all populations at risk for hepatitis C, and we don't have access to drugs in many states," said Kenneth Sherman, MD, PhD, from the University of Cincinnati.

Oct 10

Medscape - Hepatitis C Virus Containing the Threat: The New Regimens  
This week episode 4 was added to Medscape's HCV six part video series: Hepatitis C Virus: Containing the Threat
The New Regimens 
Liver specialists find that HCV patients who have comorbid conditions and treatment-resistant disease may still be candidates for combination therapies. 
View here....

Research
October 11
MedPage Today - Sustained Response with HCV Combo Drug in chronic kidney disease (CKD)
Patients with both diseases had virologic response and no failure
MedPage Today reported on trial results from the phase III trial using Glecaprevir and Pibrentasvir (Mavyret) for 12 weeks in adults with chronic HCV genotype 1-6 and chronic renal impairment, published this week in the New England Journal of Medicine.

Begin here...

On Twitter

Collaborating with others on Twitter, Henry E. Chang Tweets every day about viral hepatitis, pointing us to full text articles using an online sharing platform. Check out the following articles, shared by Mr. Chang this week.

Long-term follow-up of clinical trial patients treated for chronic HCV infection with DCV-based regimens
Daclatasvir has achieved high sustained virologic response (SVR) rates in diverse hepatitis C virus (HCV) populations. This study evaluated the long-term efficacy and safety of daclatasvir-based regimens administered during clinical studies.

Resistance characterization of LDV & SOF in HCV genotype 4
Here we characterize the resistance profile of ledipasvir (LDV) and velpatasvir (VEL)inpatients with GT4 HCV infection.

Burden of primary liver cancer & underlying etiologies from 1990 to 2015: Results from GBD 2015 study
What is the burden of liver cancer globally, what are the major risk factors for liver cancer across countries, regions, and at the global level and how did these change between 1990and 2015?

Statins & liver disease: Is it time to recommend statins to prevent liver disease progression?

There is now mounting observational evidence of a beneficial effect, a limited number of randomized controlled trials demonstrating benefit, and laboratory studies supporting biologic plausibility of hepatic protection.

Hepatitis C - Understanding factors that influence the physicians' treatment decisions

This study aimed to inform Hepatitis C (HCV) treatment by (1) better understanding the nexus of factors physicians consider when making HCV treatment decisions; (2) investigating the comparative influence and importance of specific factors and the trade-offs implicated in the decision making process; and (3)examining how much thrombocytopenia impacts treatment decisions and how it impacts treatment

Follow or view current Tweets; HenryEChang

Oct 7

Of Interest - Generic DAAs

Journal of Virus Eradication 

High sustained virological response rates using imported generic direct acting antiviral treatment for hepatitis C

Mass treatment with generic DAAs is a feasible and economical alternative route of accessing curative DAAs, where the high prices for branded alternatives prevent access to treatment.

October 05

FixHepC - Blog

A site to help patients access affordable generic hepatitis C treatment. 

Bioequivalent pharmacokinetics for generic and originator Hepatitis C Direct Acting Antivirals

Just out of embargo for AASLD 2017 is the rather innocuous sounding Abstract 1078 which says, in brief, that these generic DAAs are inarguably proven the same as the originator DAAs....

Updates On This Blog

The Liver Meeting® 2017

Blog Updates Around The Web

Hep B Blog
October is Liver Cancer Awareness Month! What’s the Hep B Connection?
According to the World Health Organization (WHO), liver cancer is the second most common cancer in the world, leading to 788,000 annual deaths worldwide.

Kevin MD
This is who’s to blame for the opioid crisis
It’s hard to imagine that law enforcement and the DEA were unable to recognize the difference between pill distributing centers and legitimate practices prescribing medications on a limited basis to individuals with documented needs. City, county and state governments gladly accepted the tax benefits, occupational license fees, and pharmaceutical license fees from these sham clinics while drug dealers drove in and out of our state to obtain prescription pain medications for sale in their hometowns. Of course, the blame for this was placed on the doctors and dentists.

HepatitisC.net
The War on Hep C is Led by Veterans
With an enemy like hepatitis C, there is a continuous uphill struggle. For those who have served in the military, your time has come. The Veterans Administration (VA) has begun to launch..


The Dark Side of Stigma with Hepatitis C (Part 3)
By now, you may have already begun to recognize the voices that blame you for living with hep C virus. You can spot the accusations in your head. By catching yourself while in the middle of a self-induced tongue lashing and calling BS, you are coming out of the dark side of stigma with hepatitis C.

Hep Blogs
Living Beyond Hepatitis C with Faith and Trust
Living beyond hepatitis C is the hope for every hep C patient. Faith and trust when you have hepatitis C is not always easy. Dealing with hep C diagnosis, searching for treatment and holding onto to hope for a new life free from hep C, every patient has walked this road.

Moving Right Along
It has been so long since I posted that I don’t know where to begin. Changes! A lot of changes happened in the last 12 months. It seems as if I am a totally different person than I was last September. But here I am in the middle of Now with the wisdom that comes from shifting and adjusting… and the joy. Always gratitude and joy.

LIFE BEYOND HEP C
10 Proactive Steps for your Hep C Battle Plan
Do you feel like you’re battling something bigger than you? Hepatitis C can feel like that. There is hope for stopping Hep C in its tracks. First and foremost, you have to develop a good Hep C battle plan.

HIV and ID Observations
What Should We Do About Persistent Low-level Viremia?
Oh my, so much to unwrap here! Because when it comes to persistent low-level viremia in treated HIV patients, there’s much agony, gnashing of teeth, and confusion.

Helpful Links

Premier Hepatitis C Websites, Blogs and Support Forums

Thanks for stopping by, check back for updates.

Tina

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