Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection

Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection - Hallo friend NEWS AN INSPIRATION, In the article you read this time with the title Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection, we have prepared well for this article you read and download the information therein. hopefully fill posts Article ECONOMY, Article HEALTH, Article POLITICS, Article SPORTS, Article TRAVELING, Article UPDATE, we write can understand. Well, happy reading.

Titre : Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection
link : Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection

Read also


Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection

Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection
Swee Lin G. Chen Yi Mei , Alexander J. Thompson, Britt Christensen, Georgina Cunningham, Lucy McDonald, Sally Bell, David Iser, Tin Nguyen, Paul V. Desmond
Published: October 24, 2017 http://ift.tt/2yKSId4

Full-Text
Download PDF
View Online

Abstract
Background/Aims
Long-term follow-up studies validating the clinical benefit of sustained virological response (SVR) in people with chronic hepatitis C (CHC) infection are lacking. Our aim was to identify rates and predictors of liver fibrosis progression in a large, well characterized cohort of CHC patients in whom paired liver fibrosis assessments were performed more than 10 years apart.

Methods
CHC patients who had undergone a baseline liver biopsy pre-2004 and a follow up liver fibrosis assessment more than 10 years later (biopsy or liver stiffness measurement (LSM) using transient elastography [FibroScan]) were identified. Subjects who had undergone a baseline liver biopsy but had no follow up fibrosis assessment were recalled for LSM. Fibrosis was categorised as mild-moderate (METAVIR F0-2 / LSM result of ≤ 9.5 kPa) or advanced (METAVIR F3-4/ LSM >9.5 kPa). The primary objective was to assess the association between SVR and the rate of liver fibrosis progression over at least 10 years, defined as an increase from mild-moderate fibrosis at baseline liver biopsy (METAVIR F0-2) to advanced fibrosis at follow-up liver fibrosis assessment.

Results
131 subjects were included in this analysis: 69% male, 82% Caucasian, 60% G1 HCV, 25% G3 HCV. The median age at F/U fibrosis staging was 57 (IQR 54–62) years with median estimated duration of infection 33-years (IQR 29–38). At F/U, liver fibrosis assessment was performed by LSM in 86% and liver biopsy in 14%. The median period between fibrosis assessments was 14-years (IQR 12–17). 109 (83%) participants had received interferon-based antiviral therapy. 40% attained SVR. At F/U, there was a significant increase in the proportion of subjects with advanced liver fibrosis: 27% at baseline vs. 46% at F/U (p = 0.002). The prevalence of advanced fibrosis did not change among subjects who attained SVR, 30% at B/L vs 25% at F/U (p = 0.343). However, advanced fibrosis became more common at F/U among subjects with persistent viremia: 10% at B/L vs 31% at F/U (p = 0.0001). SVR was independently associated with protection from liver fibrosis progression after adjustment for other variables including baseline ALT (p = 0.011), duration of HCV infection and mode of acquisition.

Conclusion
HCV eradication is associated with lower rates of liver fibrosis progression. The data support early treatment to prevent long-term liver complications of HCV infection.


Thus articles Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection

that is all articles Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection This time, hopefully can provide benefits to you all. Okay, see you in another article post.

You are now reading the article Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection the link address https://newsaninpiration.blogspot.com/2017/10/sustained-virological-response-halts.html

Subscribe to receive free email updates:

Related Posts :

0 Response to "Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection"

Post a Comment