Titre : Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis
link : Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis
Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis
Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysisJ. C.-T. Wong, H. L.-Y. Chan, Y.-K. Tse, T. C.-F. Yip, V. W.-S. Wong and G. L.-H. Wong
Version of Record online: 21 SEP 2017 | DOI: 10.1111/apt.14341
Full Text
Download PDF
View Online
Aim
To determine the effects of statin use on the risk of liver decompensation and death among patients with chronic viral hepatitis.
Methods
We conducted a population wide cohort study using a hospital based database from the Hong Kong Hospital Authority. Adults with chronic viral hepatitis without prior liver decompensation were identified from 2000 to 2012 by International Classification of Diseases, Ninth Revision, Clinical Modification, diagnostic codes. Statin use was defined as a cumulative defined daily dose of >28. Landmark analysis was used to overcome immortal time bias. Propensity score weighting was further performed to minimise baseline confounders. Primary outcome was a composite of portal hypertension related liver decompensation events, with adjustment for death as a competing risk.
We conducted a population wide cohort study using a hospital based database from the Hong Kong Hospital Authority. Adults with chronic viral hepatitis without prior liver decompensation were identified from 2000 to 2012 by International Classification of Diseases, Ninth Revision, Clinical Modification, diagnostic codes. Statin use was defined as a cumulative defined daily dose of >28. Landmark analysis was used to overcome immortal time bias. Propensity score weighting was further performed to minimise baseline confounders. Primary outcome was a composite of portal hypertension related liver decompensation events, with adjustment for death as a competing risk.
Results
A total of 69 184 patients with chronic viral hepatitis (2053 statin users and 67 131 statin non-users) were identified for the 2-year landmark analysis. After propensity score weighting of 23 baseline covariates, statin use was associated with a significant reduction in composite liver decompensation events (HR: 0.55; 95% CI: 0.36-0.83; P = .005), ascites (HR: 0.57; 95% CI: 0.36-0.92; P = .02), and a dose-dependent decrease in death (HR: 0.87; 95% CI: 0.76-0.99; P = .035) relative to no statin use.
A total of 69 184 patients with chronic viral hepatitis (2053 statin users and 67 131 statin non-users) were identified for the 2-year landmark analysis. After propensity score weighting of 23 baseline covariates, statin use was associated with a significant reduction in composite liver decompensation events (HR: 0.55; 95% CI: 0.36-0.83; P = .005), ascites (HR: 0.57; 95% CI: 0.36-0.92; P = .02), and a dose-dependent decrease in death (HR: 0.87; 95% CI: 0.76-0.99; P = .035) relative to no statin use.
Conclusions
Patients with chronic viral hepatitis who used statins have a reduced risk of liver decompensation and death compared to non-users in this propensity score weighted landmark analysis.
1 INTRODUCTION
2 METHODS
3 RESULTS
4 DISCUSSION
ACKNOWLEDGEMENTS
AUTHORSHIP
Patients with chronic viral hepatitis who used statins have a reduced risk of liver decompensation and death compared to non-users in this propensity score weighted landmark analysis.
1 INTRODUCTION
2 METHODS
3 RESULTS
4 DISCUSSION
ACKNOWLEDGEMENTS
AUTHORSHIP
Thus articles Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis
that is all articles Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis This time, hopefully can provide benefits to you all. Okay, see you in another article post.
You are now reading the article Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis the link address https://newsaninpiration.blogspot.com/2017/09/statins-reduce-risk-of-liver.html
0 Response to "Statins reduce the risk of liver decompensation and death in chronic viral hepatitis: a propensity score weighted landmark analysis"
Post a Comment