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Titre : Hepatitis C Genotype 3 Infection Pathogenesis and Treatment Horizons
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Hepatitis C Genotype 3 Infection Pathogenesis and Treatment Horizons

Clinics in Liver Disease
August 2017 Volume 21, Issue 3

Hepatitis C Genotype 3 Infection Pathogenesis and Treatment Horizons
Haripriya Maddur, MD*, Steven L. Flamm, MD

Abstract
Genotype 3 hepatitis C infection is the second most common genotype worldwide and accounts for most infections in Southeast Asia. It is a particularly ominous genotype because it has been linked to increased mortality, specifically increased late-stage liver events, accelerated development of hepatic fibrosis, and an increased risk of hepatocellular carcinoma. As new treatment regimens for hepatitis C have been emerging, treatment of genotype 3 often requires longer treatment duration with decreased response rates as compared with other genotypes.

KEY POINTS Hepatitis C genotype 3 infection is associated with increased late-stage liver events, accelerated hepatic fibrosis, and hepatocellular carcinoma.
Infection with genotype 3 infection has been linked to hepatic steatosis thought to be related to direct viral protein effect on hepatocytes.
With the advent of direct-acting antiviral therapies, infection with genotype 3 has been found to be more difficult to treat as compared with other genotypes.

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