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Titre : Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look
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Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look

J Transl Int Med. 2017 Mar; 5(1): 1–3.
Published online 2017 Mar 31. doi: 10.1515/jtim-2017-0009
Diagnosis and Treatment of Chronic Hepatitis C with Concomitant Extrahepatic Manifestations Deserves a Closer Look

Xiao-Guang Dou*,1 and Han Bai1

HCV infection and other diseases

In addition to diabetes and kidney diseases, the concomitant extrahepatic manifestations of HCV infection also include thyroid disease and haematological diseases. In recent years, more and more attention has been drawn to the increased risk of morbidity and mortality of cardiovascular diseases, secondary to atherosclerosis caused by HCV infection. However, the mechanism by which HCV infection causes extrahepatic diseases remains unclear, and maybe multifaceted, involving the replication of HCV in extrahepatic cells or increased systemic immune response.

Anti-HCV treatments, especially the use of oral DDAs without Interferon, can benefit patients with extrahepatic manifestations by ameliorating certain concomitant conditions (such as cryoglobulinemia), reducing insulin resistance and occurrence of diabetes or stroke, and improving fatigue and cognitive dysfunction.^[14]

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