Titre : Hepatitis C - Week 4 viral load and SVR
link : Hepatitis C - Week 4 viral load and SVR
Hepatitis C - Week 4 viral load and SVR
Implications of HCV RNA level at week 4 of direct antiviral treatments for Hepatitis CKay Johnson MD, MPH1, Pamela K. Green PhD2, George N. Ioannou BMBCh MS1,2,3.
ABBREVIATIONS:
DBQ = Detectable below quantification
DAQ ≤42 = Detectable above quantification with an HCV RNA level ≤42 IU/mL
DAQ>42 = Detectable above quantification with an HCV RNA level > 42 IU/mL
W4VL = week 4 viral load (the HCV RNA viral load 4 weeks after initiation of antiviral treatment)
DAQ ≤42 = Detectable above quantification with an HCV RNA level ≤42 IU/mL
DAQ>42 = Detectable above quantification with an HCV RNA level > 42 IU/mL
W4VL = week 4 viral load (the HCV RNA viral load 4 weeks after initiation of antiviral treatment)
Abstract
We aimed to determine whether the HCV viral load after four weeks of treatment (W4VL) with
direct-acting antiviral agents (DAAs) predicts sustained virologic response (SVR) in a real-world
clinical setting. We identified 21,095 patients who initiated DAA-based antiviral treatment in the
national Veterans Affairs (VA) healthcare system from 01/01/2014 to 06/30/2015. Week 4 viral load
was categorized as undetectable, detectable below quantification, detectable above quantification
with viral load ≤42 IU/mL and detectable above quantification with viral load > 42 IU/mL. Week 4
viral load was undetectable in 36.1%, detectable below quantification in 45.6%, detectable above
quantification ≤42 in 9.3%, detectable above quantification >42 in 9.1%. Detectable above
quantification was much more common and undetectable week 4 viral load much less common
when tested with the Abbott RealTime HCV assay versus the Roche COBAS AmpliPrep/COBAS
TaqMan Version 2 assay. Compared to patients with undetectable week 4 viral load (SVR=93.5%),
those with detectable below quantification (SVR=91.8%, adjusted odds ratio [AOR] 0.79, p
value=0.001), detectable above quantification ≤42 (SVR=90.0%, AOR 0.63, p-value<0.001) and
detectable above quantification >42 (SVR=86.2%, AOR 0.52, p-value<0.001) had progressively lower likelihood of achieving SVR after adjusting for baseline characteristics and treatment duration.
Among genotype 1-infected patients who were potentially eligible for 8-week sofosbuvir/ledipasvir
monotherapy, we did not find evidence that treatment for 12 weeks instead of 8 weeks was
associated with higher SVR, even among those with detectable above quantification.
We aimed to determine whether the HCV viral load after four weeks of treatment (W4VL) with
direct-acting antiviral agents (DAAs) predicts sustained virologic response (SVR) in a real-world
clinical setting. We identified 21,095 patients who initiated DAA-based antiviral treatment in the
national Veterans Affairs (VA) healthcare system from 01/01/2014 to 06/30/2015. Week 4 viral load
was categorized as undetectable, detectable below quantification, detectable above quantification
with viral load ≤42 IU/mL and detectable above quantification with viral load > 42 IU/mL. Week 4
viral load was undetectable in 36.1%, detectable below quantification in 45.6%, detectable above
quantification ≤42 in 9.3%, detectable above quantification >42 in 9.1%. Detectable above
quantification was much more common and undetectable week 4 viral load much less common
when tested with the Abbott RealTime HCV assay versus the Roche COBAS AmpliPrep/COBAS
TaqMan Version 2 assay. Compared to patients with undetectable week 4 viral load (SVR=93.5%),
those with detectable below quantification (SVR=91.8%, adjusted odds ratio [AOR] 0.79, p
value=0.001), detectable above quantification ≤42 (SVR=90.0%, AOR 0.63, p-value<0.001) and
detectable above quantification >42 (SVR=86.2%, AOR 0.52, p-value<0.001) had progressively lower likelihood of achieving SVR after adjusting for baseline characteristics and treatment duration.
Among genotype 1-infected patients who were potentially eligible for 8-week sofosbuvir/ledipasvir
monotherapy, we did not find evidence that treatment for 12 weeks instead of 8 weeks was
associated with higher SVR, even among those with detectable above quantification.
In summary
detectable below quantification and detectable above quantification W4VL are very common in real-world practice, contrary to what was reported in clinical trials, and strongly predict reduced SVR across genotypes and clinically-relevant patient subgroups. Whether and how week 4 viral load
results should influence treatment decisions requires further study.
detectable below quantification and detectable above quantification W4VL are very common in real-world practice, contrary to what was reported in clinical trials, and strongly predict reduced SVR across genotypes and clinically-relevant patient subgroups. Whether and how week 4 viral load
results should influence treatment decisions requires further study.
Keywords
Response-guided therapy
Full Text
Download PDF
Link Provided By Henry E. Chang via Twitter
Thus articles Hepatitis C - Week 4 viral load and SVR
that is all articles Hepatitis C - Week 4 viral load and SVR This time, hopefully can provide benefits to you all. Okay, see you in another article post.
You are now reading the article Hepatitis C - Week 4 viral load and SVR the link address https://newsaninpiration.blogspot.com/2017/06/hepatitis-c-week-4-viral-load-and-svr.html
0 Response to "Hepatitis C - Week 4 viral load and SVR"
Post a Comment