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Titre : Update on the Development of Simeprevir as Part of the Triple Combination With AL-335 and Odalasvir (JNJ-4178)
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Update on the Development of Simeprevir as Part of the Triple Combination With AL-335 and Odalasvir (JNJ-4178)

Update on the Development of Simeprevir as Part of the Triple Combination With AL-335 and Odalasvir (JNJ-4178)

STOCKHOLM, April 24, 2017 /PRNewswire/ --Medivir AB (Nasdaq Stockholm: MVIR) today communicates an update on the status of the development of JNJ-4178, the triple combination of simeprevir, odalasvir and AL-335, following The International Liver Congress™ 2017 of the European Association for the Study of the Liver (EASL), which was held in Amsterdam, on 19-23 April.

Data from an ongoing phase II study presented at The International Liver Congress™ 2017 demonstrate that this regimen has the potential to shorten treatment duration, offer high efficacy and is generally well tolerated in those whose disease is caused by hepatitis C virus (HCV) genotype 1 (GT1), one of the most prevalent causes of hepatitis C globally. The three-drug regimen achieved 100% SVR12 for 6- and 8-week treatment duration in treatment-naïve, GT1, non-cirrhotic patients. The three-drug combination did not have sufficient efficacy in patients with HCV genotype 3 to justify further development in this patient population. All-oral combination regimens, containing odalasvir, AL-335 with or without simeprevir were generally safe and well tolerated. The safety and efficacy of JNJ-4178 in cirrhotic patients is currently under investigation as part of this phase II study. Further information on this trial can be found at http://ift.tt/PmpYKN (NCT02569710).
                          

Enrolment has recently been completed into the global phase IIb OMEGA-1 study of JNJ-4178. This open-label study is assessing the efficacy and safety of JNJ-4178 in non-cirrhotic patients with HCV genotypes 1, 2, 4, 5 and 6. Further information on the study can be found at http://ift.tt/PmpYKN (NCT02765490).

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